Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylate → 4-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

HRID 1895999ノート

反応式

HRID 1895999 の反応式
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]2)[CH:21]=[C:22]([F:24])[CH:23]=1>>[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[CH:21]=[C:22]([F:24])[CH:23]=1

参加物

3

反応物 2

HCID 68726123Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

生成物 1

HCID 689794914-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

実験手順

The title compound was prepared following the procedure described for the Compound of Example 3, using the Compound of Example 247 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used for the next step without further purification.

後処理

  1. customAfter the usual work-up procedure, the crude was used for the next step without further purification

出典と根拠

ORDレコード
ord-76778855337f410894fdcfa7854d8862
出典データセット
uspto-grants-2013_08
特許番号
US08518916B2

反応ノート

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