Hydrochloric Acid → HCID 16788087、化合物

HRID 1896015ノート

反応式

HRID 1896015 の反応式
[OH-].[K+].[N+:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([O:20]CC)=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)([O-:5])=[O:4].Cl>CO.O>[N+:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)([O-:5])=[O:4]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 60631682HCID 60631682、化合物

生成物 1

HCID 16788087HCID 16788087、化合物収率 134.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of KOH (0.46 g, 8.16 mmol) in methanol (30 mL) and water (30 mL) was added Compound 258a (1.14 g, 4.08 mmol). The solution was stirred at r.t. for 1.5 hours, poured into water, acidified with 2M HCl and extracted with EtOAc. The combined organic layers were washed with brine, dried on Na2SO4 and evaporated to dryness in vacuo to afford the title product (1.38 g).

後処理

  1. extractionextracted with EtOAc
  2. washThe combined organic layers were washed with brine
  3. customdried on Na2SO4
  4. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-3a325d3a9a864dac870a7fcc5190a601
出典データセット
uspto-grants-2013_08
特許番号
US08518916B2

反応ノート

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