2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine → 2-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

HRID 1896035ノート

反応式

HRID 1896035 の反応式
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[Br:17][C:18]1[N:23]=[C:22]([C:24]#[C:25][CH:26]=[C:27]2[CH2:32][CH2:31][N:30](C(OC(C)(C)C)=O)[CH2:29][CH2:28]2)[CH:21]=[CH:20][CH:19]=1>>[Br:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]([C:24]#[C:25][CH:26]=[C:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:23]=1

参加物

3

反応物 2

HCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridineHCID 87641844Tert-butyl 4-[3-(6-bromopyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate

生成物 1

HCID 876422122-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

実験手順

The title product was prepared following the method described for the Compound of Example 3 but using as starting material Compound 305a instead of the Compound of Example 2 and stirring at ambient temperature for 3 days. The reaction mixture was evaporated to dryness in vacuo, taking up the residue several times with chloroform to remove excess trifluoroacetic acid.

後処理

  1. customThe reaction mixture was evaporated to dryness in vacuo
  2. customto remove excess trifluoroacetic acid

出典と根拠

ORDレコード
ord-213125f6597a4d6fa6d15b244e585472
出典データセット
uspto-grants-2013_08
特許番号
US08518916B2

反応ノート

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