2-Chloro-6-methyl-3-nitropyridine → 2-[1-(6-Methyl-3-nitropyridin-2-yl)piperidin-4-yl]but-3-yn-2-ol
反応式
CC1N=C(C#CC(C2CCNCC2)O)C=CC=1.[NH:18]1[CH2:23][CH2:22][CH:21]([C:24]([OH:28])([C:26]#[CH:27])[CH3:25])[CH2:20][CH2:19]1.Cl[C:30]1[C:35]([N+:36]([O-:38])=[O:37])=[CH:34][CH:33]=[C:32]([CH3:39])[N:31]=1>>[CH3:39][C:32]1[N:31]=[C:30]([N:18]2[CH2:23][CH2:22][CH:21]([C:24]([OH:28])([C:26]#[CH:27])[CH3:25])[CH2:20][CH2:19]2)[C:35]([N+:36]([O-:38])=[O:37])=[CH:34][CH:33]=1参加物
4
実験手順
The title compound was prepared as described for the compound of Example 237 but starting from Compound 312b instead of Compound 237a and 2-chloro-6-methyl-3-nitropyridine instead of 2-bromo-3-nitropyridine. After the work-up, the residue was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with PE-EtOAc from PE:EtOAc 9:1 affording the title products as yellow oil. Yield: 93%.