Thiophene-3-boronic acid → 2-Phenyl-6-(thiophen-3-yl)pyrimidine-4-carboxylic acid
反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([C:14]([OH:16])=[O:15])[CH:3]=1.[S:17]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18]1>>[C:8]1([C:6]2[N:5]=[C:4]([C:14]([OH:16])=[O:15])[CH:3]=[C:2]([C:19]3[CH:20]=[CH:21][S:17][CH:18]=3)[N:7]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1参加物
3
実験手順
This compound was prepared using a method analogous to that of Example 32, step 32.1, 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid replacing intermediate 14.1 and thiophene-3-boronic acid replacing phenylboronic acid. The crude was however crystallized (EtOH/H20 2/1). LC-MS (A): tR=1.03 min; [M+H]+: 283.03.
後処理
- customThis compound was prepared
- customThe crude was however crystallized (EtOH/H20 2/1)
出典と根拠
- ORDレコード
- ord-b2881ada9da5452398a133824c769373
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518912B2
反応ノート
読み込み中…