関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloro-5-(trifluoromethyl)phenylboronic acid | HCID 2782670 | — |
| 反応物 | N-(5-Bromopyrazin-2-YL)-2,6-difluorobenzamide | HCID 53415197 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-{5-[2-chloro-5-(trifluoromethyl)phenyl]pyrazin-2-yl}-2,6-difluorobenzamide | HCID 11546102 | — |
反応手順
A mixture of 2-chloro-5-trifluoromethyl-benzeneboronic acid (a, 5 mmol), N-(5-bromo-pyrazin-2-yl)-2,6-difluoro-benzamide (b, 5 mmol), palladium catalyst (0.30 mmol), potassium carbonate (1 g) in dry 1,4-dioxane (20 mL) was heated at 100° C. for 24 h. The mixture was taken up with ethyl acetate (EtOAc) (100 mL), washed with water (2×100 mL) and dried over Na2SO4. The oil obtained on concentration was purified by flash chromatography followed by recrystallization to give Compound 1 as a yellowish solid (0.19 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08518950B2 |
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| 出典データセット | uspto-grants-2013_08 |
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| ORD ID | ord-80ab8f0babcb4f2c8f71c579f7e1d452 |
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| 出典メモ | uspto-grants-2013_08 |
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