Water → 6-chloro-3-(6-chloropyrazin-2-yl)-3H-imidazo[4,5-c]pyridine 6-chloro-1-(6-chloropyrazin-2-yl)-1H-imidazo[4,5-c]pyridine

HRID 1896207ノート

反応式

HRID 1896207 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[NH:8][CH:9]=[N:10][C:4]=2[CH:3]=1.[Cl:11][C:12]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=1.[F-].[Cs+].O>CS(C)=O>[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[N:8]([C:14]3[CH:15]=[N:16][CH:17]=[C:12]([Cl:11])[N:13]=3)[CH:9]=[N:10][C:4]=2[CH:3]=1.[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[N:8]=[CH:9][N:10]([C:12]3[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=3)[C:4]=2[CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 25953Cesium fluorideHCID 785042,6-DichloropyrazineHCID 218138956-Chloro-3H-imidazo(4,5-c)pyridine

生成物 1

HCID 866543176-chloro-3-(6-chloropyrazin-2-yl)-3H-imidazo[4,5-c]pyridine 6-chloro-1-(6-chloropyrazin-2-yl)-1H-imidazo[4,5-c]pyridine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

A mixture of 6-chloro-3H-imidazo[4,5-c]pyridine (4.6 g, 30 mmol), 2,6-dichloropyrazine (6 g, 40.5 mmol) and CsF (9.1 g, 60 mmol) in dry DMSO (80 mL) was stirred at room temperature for 20 h under N2. The mixture was poured into water (50 mL) with stirring. The formed precipitate was collected by filtration. The filter cake was suspended in MeOH (20 mL) and filtered again. The filter cake was collected and dried in vacuum which gave a mixture of title compounds 18a & 17a as a white solid (5.0 g, 62.9%).

後処理

  1. stirringwith stirring
  2. filtrationThe formed precipitate was collected by filtration
  3. filtrationfiltered again
  4. customThe filter cake was collected
  5. customdried in vacuum which
  6. customgave

出典と根拠

ORDレコード
ord-46677eac6d294294a28584219bfc6d41
出典データセット
uspto-grants-2013_08
特許番号
US08518952B2

反応ノート

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