Diethyl 2-methyl-2-(4-(4-methylpiperazin-1-yl)phenyl)malonate → 2-(4-(4-Methylpiperazin-1-yl)phenyl)propanoic acid
反応式
[CH3:1][C:2]([C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)(C(OCC)=O)[C:3]([O:5]CC)=[O:4]>Cl>[CH3:25][N:22]1[CH2:21][CH2:20][N:19]([C:16]2[CH:15]=[CH:14][C:13]([CH:2]([CH3:1])[C:3]([OH:5])=[O:4])=[CH:18][CH:17]=2)[CH2:24][CH2:23]1参加物
3
実験手順
A solution of diethyl 2-methyl-2-(4-(4-methylpiperazin-1-yl)phenyl)malonate (3.50 g, 10.0 mmol) in conc. HCl (20 ml) was stirred for 18 h at reflux in a sealed tube. The reaction mixture was concentrated and co-distilled with toluene to afford (1.7 g, 70%) of 2-(4-(4-methylpiperazin-1-yl)phenyl)propanoic acid as dark brown solid.
後処理
- temperatureat reflux in a sealed tube
- concentrationThe reaction mixture was concentrated and co-distilled with toluene
出典と根拠
- ORDレコード
- ord-d3e68d67f0704c95b58493ca2496ab8b
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518948B2
反応ノート
読み込み中…