Ammonia → (1R,3S)-3-(benzylamino)cyclopentanecarboxamide
反応式
[NH3:1].[CH2:2]([NH:9][C@H:10]1[CH2:14][CH2:13][C@@H:12]([C:15]([O:17]C)=O)[CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[CH2:2]([NH:9][C@H:10]1[CH2:14][CH2:13][C@@H:12]([C:15]([NH2:1])=[O:17])[CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
4
実験手順
Ammonia gas was passed into a solution of (1R,3S)-methyl 3-(benzylamino)cyclopentanecarboxylate (250 mg, 1.14 mmol) in MeOH (5 ml) at −78° C. in a steel bomb. The reaction mixture was slowly warmed to room temperature, heated further to 100° C. and stirred for 24 h. The reaction mixture was concentrated and dried under vacuum to afford 250 mg of (1R,3S)-3-(benzylamino)cyclopentanecarboxamide with 50% purity as brown liquid which was proceeded as crude compound for the next step.
後処理
- temperatureheated further to 100° C.
- concentrationThe reaction mixture was concentrated
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-77295d58d81445e590f7d49fdfa11283
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518948B2
反応ノート
読み込み中…