Ammonia → 1-(Aminomethyl)-4-propylpyrrolidin-2-one

HRID 1896380ノート

反応式

HRID 1896380 の反応式
Cl[CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11].[NH3:12]>C1(C)C=CC=CC=1>[NH2:12][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11]

参加物

4

反応物 2

HCID 222Ammonia2 回HCID 536292161-(Chloromethyl)-4-propylpyrrolidin-2-one

生成物 1

HCID 536292181-(Aminomethyl)-4-propylpyrrolidin-2-one

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 1-(chloromethyl)-4-propylpyrrolidin-2-one x63 (41.34 g, 0.235 mol) in toluene (350 ml) is added dropwise at −78° C. to liquid ammonia (300 ml). At the end of the addition, the temperature is raised slowly to room temperature, and ammonia of the crude mixture is allowed to distill at room temperature overnight. Filtration of the reaction mixture and subsequent evaporation lead to 55 g of the crude 1-(aminomethyl)-4-propylpyrrolidin-2-one x76 which is used without further purification.

後処理

  1. additionAt the end of the addition
  2. distillationto distill at room temperature overnight
  3. filtrationFiltration of the reaction mixture and subsequent evaporation lead to 55 g of the crude 1-(aminomethyl)-4-propylpyrrolidin-2-one x76 which
  4. customis used without further purification

出典と根拠

ORDレコード
ord-074e5cebe0054f61a821410da7743c6c
出典データセット
uspto-grants-2013_08
特許番号
US08518943B2

反応ノート

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