関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Bromobenzyl bromide | HCID 69979 | — |
| 反応物 | tert-butyl N-(3-hydroxyphenyl)carbamate | HCID 312485 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Tert-butyl 3-(3-bromobenzyloxy)phenylcarbamate | HCID 59418705 | — |
反応手順
To tert-butyl 3-hydroxyphenylcarbamate (0.245 g, 1.17 mmol), K2CO3 (404 mg, 2.93 mmol), and 3-bromobenzyl bromide (322 mg, 1.29 mmol) was added anhydrous DMF (5 mL). The reaction mixture was heated to 60° C. for 18 hours. The reaction mixture was cooled to rt, poured into water and the resulting precipitate was collected by filtration and washed with water to provide the desired product tert-butyl 3-(3-bromobenzyloxy)phenylcarbamate (34A) with sufficient purity for subsequent use.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08518970B2 |
|---|
| 出典データセット | uspto-grants-2013_08 |
|---|
| ORD ID | ord-94bb1667a57f46eb981a0628217bd1d1 |
|---|
| 出典メモ | uspto-grants-2013_08 |
|---|
