Sodium Dithionite → 5-Amino-2-morpholin-4-yl-1,3-benzoxazole

HRID 1896763ノート

反応式

HRID 1896763 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:10]=3[N:11]=2)[CH2:3][CH2:2]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(O)C.O.O>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:10]=3[N:11]=2)[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 24489Sodium DithioniteHCID 127114612-Morpholino-5-nitrobenzo[d]oxazole

生成物 1

HCID 167689435-Amino-2-morpholin-4-yl-1,3-benzoxazole収率 30.7%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 19096565Water ethanol溶媒

実験手順

A solution of 2-morpholino-5-nitrobenzo[d]oxazole (130 mg, 0.52 mmol) in ethanol/water 1:1 v/v (10 mL) was treated with sodium dithionite (182 mg, 1.04 mmol) at room temperature and then refluxed for 16 h. After cooling, the mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4 and evaporated to afford 35 mg (30%) of the title compound.

後処理

  1. temperaturerefluxed for 16 h
  2. temperatureAfter cooling
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over anhydrous MgSO4
  5. customevaporated

出典と根拠

ORDレコード
ord-4c407d27787a47e6a75b2e15a183ad34
出典データセット
uspto-grants-2013_08
特許番号
US08518980B2

反応ノート

読み込み中…