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Methanesulfonyl chloride → 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanyl methylsulfonyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanol | HCID 22869531 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanyl methylsulfonyl ether | HCID 86750300 | — |
反応手順
A 3.5 g sample of the alcohol from step 471a above was dissolved in 25 mL of methylene chloride and treated with methanesulfonyl chloride an TEA at 0° C. for 2 hours. The reaction mixture was washed with NaHCO3 solution and water, and the solvent was removed. The residue was chromatographed on silica gel to give 3 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726182 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-d35336a8d63f46faa12cbe3c8194e4f3 |
| 出典メモ | uspto-grants-1998_03 |