3-Phenyl-5-trifluoromethyl-isoxazole-4-carboxylic acid → [3-(4-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-methanol

HRID 1897159ノート

反応式

HRID 1897159 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13](O)=[O:14])=[C:11]([C:16]([F:19])([F:18])[F:17])[O:10][N:9]=2)=[CH:4][CH:3]=1.C1(C2C(C(O)=O)=C(C(F)(F)F)ON=2)C=CC=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][OH:14])=[C:11]([C:16]([F:18])([F:17])[F:19])[O:10][N:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 42478083-Phenyl-5-trifluoromethyl-isoxazole-4-carboxylic acidHCID 684436265-(Trifluoromethyl)-3-(4-fluorophenyl)isoxazole-4-carboxylic acid

生成物 1

HCID 68443889[3-(4-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-methanol収率 56%

実験手順

As described for example 128d, 3-(4-fluoro-phenyl)-5-trifluoromethyl-isoxazole-4-carboxylic acid (3.0 g, 11 mmol), instead of 3-phenyl-5-trifluoromethyl-isoxazole-4-carboxylic acid, was converted to the title compound (1.58 g, 56%) which was obtained as a yellow solid. MS: m/e=262.0 [M+H]+.

出典と根拠

ORDレコード
ord-397323e0732a4ff7bfb5e8ffa14693e9
出典データセット
uspto-grants-2013_08
特許番号
US08518974B2

反応ノート

読み込み中…