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Water → 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| 反応物 | 3-ethyl-1H-pyrazol-5-amine | HCID 21991095 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 58255148 | — |
反応手順
A mixture of 5-ethyl-1H-pyrazol-3-amine (1.00 g, 6.77 mmol), 2,4,5-trichloropyrimidine (1.24 g, 6.77 mmol) and Na2CO3 (1.79 g, 16.9 mmol) in iso-propanol (15 mL) was stirred in a sealed vial at rt for two days. Water (10 mL) was added. The solid was collected by filtration, washed with water (10 mL) and dried to give 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine as a light yellow solid; ESMS m/z 258.0 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08519129B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-6c65bccc55a445cd91fabe284790f665 |
| 出典メモ | uspto-grants-2013_08 |