Acetyl chloride → n-(5-Methoxy-2-methylphenyl)acetamide
反応式
C(N(CC)CC)C.[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH3:17])=[C:14]([CH:16]=1)[NH2:15].[C:18](Cl)(=[O:20])[CH3:19]>C(Cl)Cl>[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH3:17])=[C:14]([NH:15][C:18](=[O:20])[CH3:19])[CH:16]=1参加物
5
実験手順
To a solution of triethylamine (2.9 g, 14.4 mmol) and 5-methoxy-2-methylaniline (1.0 g, 7.2 mmol) in DCM (30 mL) at 0° C., was added acetyl chloride (0.57 g, 7.2 mmol) dropwise. The mixture was stirred at room temperature for 1 hour. The reaction was quenched with saturated ammonium chloride aqueous solution, and extracted with DCM. The organic layer was dried over Na2SO4 and concentrated to give N-(5-methoxy-2-methylphenyl)acetamide as needle-shaped crystals. The crude product was used in the next step without further purification.
後処理
- customThe reaction was quenched with saturated ammonium chloride aqueous solution
- extractionextracted with DCM
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-308b3493c5904aa893672847f6a87713
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08519129B2
反応ノート
読み込み中…