Hydrochloric Acid → N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrogen chloride (1:2)

HRID 1897737

反応式

HRID 1897737 の反応式
[ClH:1].[NH2:2][C:3]1(S([O-])(=O)=O)[NH:7][C:6]2[CH2:8][CH2:9][CH:10]([NH:12][CH2:13][CH2:14][CH3:15])[CH2:11][C:5]=2[S:4]1>NC1SC2CC(NCCC)CCC=2N=1.C(OC(C)C)(=O)C>[ClH:1].[ClH:1].[NH2:2][C:3]1[S:4][C:5]2[CH2:11][CH:10]([NH:12][CH2:13][CH2:14][CH3:15])[CH2:9][CH2:8][C:6]=2[N:7]=1

参加物

5

反応物 2

HCID 313Hydrochloric Acid2 回HCID 86623290HCID 86623290、化合物2 回

生成物 1

HCID 13670715N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrogen chloride (1:2)

試薬・触媒・溶媒 2

HCID 48854,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine溶媒2 回HCID 7915Isopropyl Acetate溶媒2 回

反応条件

温度
15 °C

実験手順

In another embodiment, of 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole sulfonate or halide salts (8) may be converted to an HCl salt using a concentrated solution of HCl and isopropyl acetate (IPAC). In such embodiments, 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole sulfonate or halide salt (8) may be dissolved in IPAC and cooled to about 15° C. HCl (gas) may then be bubbled into the slurry for from about 0.5 hours to 3 hours to produce 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride (10), after which the mixture may be filtered, washed with an inert solvent, such as, for example, IPAC and dried under vacuum at room temperature. A detailed example of this synthesis may be found in Example 13.

後処理

  1. customHCl (gas) may then be bubbled into the slurry for from about 0.5 hours to 3 hours

出典と根拠

ORDレコード
ord-f9c5fa16aa1d472eb4c38776087d571c
出典データセット
uspto-grants-2013_08
特許番号
US08519148B2

関連ノート

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