Ammonia → HCID 59578441、化合物
反応式
C[O:2][C:3](=O)[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])[CH:11]=1.[NH3:21]>>[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[C:10]1[CH:11]=[C:6]([CH2:5][CH2:4][C:3]([NH2:21])=[O:2])[CH:7]=[N:8][CH:9]=1参加物
3
実験手順
A mixture of 3-[5-(2,3-dichloro-phenyl)-pyridin-3-yl]-propionic acid methyl ester and ammonia (7N in MeOH, 2 ml, 14.00 mmol) was stirred at room temperature for 24 hours. Ammonia (7N in MeOH, 1 ml, 7.00 mmol) was added, and the reaction mixture was stirred for another 24 hours. Solvent was removed in vacuo. The crude product was used in the next step without purification. ESI-MS m/z: 295 [M+1]+.
後処理
- stirringthe reaction mixture was stirred for another 24 hours
- customSolvent was removed in vacuo
- customThe crude product was used in the next step without purification
出典と根拠
- ORDレコード
- ord-a3fc54d7c3904939a4e591ac30b719b2
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08519142B2
反応ノート
読み込み中…