Aluminum(III) Chloride → Methyl 2-hydroxy-4-(methylamino)-5-nitrobenzoate
反応式
C[O:2][C:3]1[CH:12]=[C:11]([NH:13][CH3:14])[C:10]([N+:15]([O-:17])=[O:16])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)CCl>[OH:2][C:3]1[CH:12]=[C:11]([NH:13][CH3:14])[C:10]([N+:15]([O-:17])=[O:16])=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]参加物
4
実験手順
The title compound was prepared following the procedure described for Step-5 of Intermediate-1 using methyl 2-methoxy-4-(methylamino)-5-nitrobenzoate (4.00 g, 0.0166 mmol), anhydrous aluminium chloride (6.64 g, 0.0499 mmol) and EDC to afford 4.00 g of crude desired product. 1HNMR (DMSO-d6): δ 2.93 (d, J=5.1 Hz, 3H), 3.86 (s, 3H), 6.28 (s, 1H), 8.48 (bs, 1H), 8.59 (s, 1H), 11.15 (s, 1H).
後処理
- customThe title compound was prepared
出典と根拠
- ORDレコード
- ord-a340d1cc49bf417781b49ba978a04b2b
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08519149B2
反応ノート
読み込み中…