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4-(tert-Butyl)-2-(tributylstannyl)pyridine → 2-(4-Trifluoromethyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(tert-Butyl)-2-(tributylstannyl)pyridine | HCID 57516631 | — |
| 反応物 | 2-(Tributylstannyl)-4-(trifluoromethyl)pyridine | HCID 57516634 | — |
| 反応物 | 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide | HCID 58438532 | — |
| 反応物 | 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide | HCID 86657873 | — |
| 生成物 | 2-(4-Trifluoromethyl-pyridin-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide | HCID 58438573 | — |
反応手順
Prepared according to the procedure outlined in Example 111, steps 4-5 substituting 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyano-piperidine-1-carbonyl)-2,2-dimethyl-propyl]-amide for 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(4-cyano-piperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-amide and 2-tributylstannanyl-4-trifluoromethyl-pyridine for 4-tert-butyl-2-(tributylstannyl)pyridine. MS: (M+H)+=514.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08518945B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-8d2b00c2130346d597cfc4243cb5da2f |
| 出典メモ | uspto-grants-2013_08 |