Ethanol → 3-Chloro-7-[N-(2'-cyanobiphenyl-4-yl)methyl-N-methylamino]-5-ethylpyrazolo[1,5-a]pyrimidine
反応式
[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([NH:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4C4NN=NN=4)=[CH:15][CH:14]=3)=[CH:9][C:8]([CH2:30][CH3:31])=[N:7][C:6]=12.[C:32](C1C=CC=CC=1C1C=CC(CNC)=CC=1)#[N:33].[CH2:49](O)C>>[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([N:11]([CH2:12][C:13]3[CH:14]=[CH:15][C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:32]#[N:33])=[CH:17][CH:18]=3)[CH3:49])=[CH:9][C:8]([CH2:30][CH3:31])=[N:7][C:6]=12参加物
4
実験手順
3.1 g (14.4 mmol) of the chloro compound (Example 3, Step A) and 3.2 g (14.4 mmol) of the amine (Example 1, Step C) were heated in 75 ml ethanol according to Example 4, Step C. The title compound was obtained as an oil after chromatography (silica gel; dichloromethane with ascending polarity by addition of up to 3% ethanol).