1-Ethylpiperidin-3-one hydrochloride → HCID 19694168、化合物

HRID 1898932

反応式

HRID 1898932 の反応式
[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([N:20]1[CH2:25][CH2:24][CH2:23][C:22](=[O:26])[CH2:21]1)[CH3:19]>>[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[C:9]1[C:22]1([OH:26])[CH2:23][CH2:24][CH2:25][N:20]([CH2:18][CH3:19])[CH2:21]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 141991521-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine

生成物 1

HCID 19694168HCID 19694168、化合物

実験手順

Following the procedure of Example 13 and using 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.60 g, 2.5 mmol) and (0.36g, 2.8 mmol) of N-ethyl-3-piperidone gave the free base of the title compound which was purified by flash chromatography on silica gel eluting with EtOAc to give, after preparation of the salt, the dihydrochloride, 0.59 hydrate as an amorphous solid, 0.30 g (26%):

出典と根拠

ORDレコード
ord-975bfa36142e4cabb77dffbd527c74ec
出典データセット
uspto-grants-1996_11
特許番号
US05571819

関連ノート

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