化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 1-[2-(2-Carboxy-4-chlorophenyl)amino-2-oxoethyl]-4-(2-oxo-1-benzimidazolinyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one | HCID 88638 | — |
| 反応物 | 5-Chloro-2-((2-chloroacetyl)amino)benzoic acid | HCID 4179825 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-[2-(2-Carboxy-4-chlorophenyl)amino-2-oxoethyl]-4-(2-oxo-1-benzimidazolinyl)piperidine | HCID 15221663 | — |
反応手順
7.94 g (32 mmol) of the compound from Example II and 8.26 g (40 mmol) of 4-(2-oxo-1-benzimidazolinyl)piperidine (Aldrich) are initially introduced in 120 ml of DMF. The mixture is treated with 5.52 g (40 mmol) of potassium carbonate and 0.45 g (3 mmol) of sodium iodide and stirred overnight at room temperature. The batch is diluted with 600 ml of H2O and the product is precipitated at pH 5 by dropwise addition of 33 ml of 1N hydrochloric acid. The precipitate is filtered off with suction, stirred with 300 ml of diethyl ether and dried in a high vacuum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05571921 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-b10f7b49606e4a6586371f77f5c2fca8 |
| 出典メモ | uspto-grants-1996_11 |