Benzenesulfonyl chloride, 2,5-dimethyl- → 2,5-Dimethyl-N-(4-chloro-3-methyl-5-isoxazolyl)benzenesulfonamide

反応式

[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Cl:8].[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[S:17](Cl)(=[O:19])=[O:18]>>[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[S:17]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Cl:8])(=[O:18])=[O:19]

参加物

反応物 2

HCID 87910Benzenesulfonyl chloride, 2,5-dimethyl-

HCID 105828224-Chloro-3-methyl-1,2-oxazol-5-amine

生成物 1

HCID 186173352,5-Dimethyl-N-(4-chloro-3-methyl-5-isoxazolyl)benzenesulfonamide収率 82%

実験手順

2,5-Dimethyl-N-(4-chloro-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-chloro-3-methylisoxazole and 2,5-dimethylbenzenesulfonyl chloride according to the procedures described in Example 40b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a light yellow solid, m.p. 92°-93° C., yield 82%.

後処理

customThe crude product was purified by recrystallization from ethyl acetate/hexanes
customto give a light yellow solid, m.p. 92°-93° C., yield 82%

出典と根拠

ORDレコード: ord-86523afc076c4093a96ffb5a03323438
出典データセット: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05571821

反応ノート

読み込み中…

参加物