Benzenesulfonyl chloride → HCID 18617378、化合物

反応式

[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH2:11][CH3:12].[C:13]1([S:19](Cl)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:19]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:21])=[O:20])[CH3:12]

参加物

反応物 2

HCID 7369Benzenesulfonyl chloride

HCID 233729304-ethyl-3-(trifluoromethyl)-1,2-oxazol-5-amine

生成物 1

HCID 18617378HCID 18617378、化合物収率 72%

実験手順

N-(4-Ethyl-3-trifluoromethyl-5-isoxazolyl)benzenesulfonamide was prepared, using the method of Example 90, from 5-amino-4-ethyl-3-trifluoromethylisoxazole and benzenesulfonyl chloride in 72% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give white needles, m.p. 105°-106° C.

後処理

customPurification
customwas achieved by recrystallization from ethyl acetate/hexanes
customto give white needles, m.p. 105°-106° C.

出典と根拠

ORDレコード: ord-420e3c999a1b44b28b1d5e722ac49100
出典データセット: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05571821

反応ノート

読み込み中…

参加物