Fumaric Acid → HCID 67623235、化合物

HRID 1899835ノート

反応式

HRID 1899835 の反応式
[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>C(O)C>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 444972Fumaric AcidHCID 545585415-Benzyl-3-[3-(morpholin-4-yl)-3-phenylpropyl]-1,3-oxazolidin-2-one

生成物 1

HCID 67623235HCID 67623235、化合物収率 100.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5-benzyl-3-(3-morpholino-3-phenylpropyl)-1,3-oxazolidin-2-one (0.26 g, 0.68 mmol) prepared in the same manner as is described in Example 9 and fumaric acid (0.08 g, 0.68 mmol) were dissolved in ethanol. From the resulting solution, ethanol was removed by distillation under reduced pressure. Water was added to the residue and then the resulting solution was concentrated. After the concentration was repeated for three times, the residue was dried in vacuum to obtain 0.34 g of the titled compound as a pale scarlet amorphous product (yield: 100%).

後処理

  1. customFrom the resulting solution, ethanol was removed by distillation under reduced pressure
  2. additionWater was added to the residue
  3. concentrationthe resulting solution was concentrated
  4. concentrationAfter the concentration
  5. customthe residue was dried in vacuum

出典と根拠

ORDレコード
ord-b23d4cc7af3a4edfa89c0ca1e7942988
出典データセット
uspto-grants-1996_11
特許番号
US05574030

反応ノート

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