Water → 5-[(5-Methylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

HRID 1900100ノート

反応式

HRID 1900100 の反応式
[CH3:1][C:2]1[O:6][C:5]([CH:7]=O)=[CH:4][CH:3]=1.[S:9]1[CH2:15][C:13](=[O:14])[NH:12][C:10]1=[S:11].C([O-])(=O)C.[Na+].O>C(O)(=O)C>[CH3:1][C:2]1[O:6][C:5]([CH:7]=[C:15]2[S:9][C:10](=[S:11])[NH:12][C:13]2=[O:14])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 120975-MethylfurfuralHCID 517045Sodium AcetateHCID 1201546Rhodanine

生成物 1

HCID 34209755-[(5-Methylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one収率 89.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 5.51 g (50.0 mmol) of 5-methylfuran-2-carboxaldehyde (purchased from Wako Junyaku Kogyo), 6.66 g (50.0 mmol) of rhodanine (purchased from Tokyo Kasei) 12.3 g (150 mmol) of anhydrous sodium acetate (purchased from Kokusan Kagaku) in 35 ml of acetic acid (purchased from Wako Junyaku Kogyo) was refluxed for 30 minutes, cooled and added to 500 ml of water, and the precipitate was collected, washed with water, ethanol and ether in order and dried to give 10.04 g (yield: 89.1%) of of (5-methylfurfurylidene)rhodanine as an orange brown crystalline.

後処理

  1. temperaturewas refluxed for 30 minutes
  2. temperaturecooled
  3. customthe precipitate was collected
  4. washwashed with water, ethanol and ether in order
  5. customdried

出典と根拠

ORDレコード
ord-f96be1684e804958a0a5edce17092d38
出典データセット
uspto-grants-1996_11
特許番号
US05574062

反応ノート

読み込み中…