Morpholine → Chloromethyl 4-morpholinecarboxylate
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]([O:10][CH2:11][Cl:12])=[O:9]>C(Cl)Cl>[N:1]1([C:8]([O:10][CH2:11][Cl:12])=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1参加物
4
実験手順
Morpholine (1 equiv.) is slowly added to a 0.1M solution of chloromethyl chloroformate (10 equiv.) in methylene chloride at low temperature. After 15 min at low temperature and a suitable time at 25° C. the reaction mixture is filtered and concentrated to dryness under reduced pressure. The residue is purified by flash chromatography giving chloromethyl morpholine-4-carboxylate.
後処理
- filtrationa suitable time at 25° C. the reaction mixture is filtered
- concentrationconcentrated to dryness under reduced pressure
- customThe residue is purified by flash chromatography
出典と根拠
- ORDレコード
- ord-749605c877ab4c14aee248009df64e67
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05574097
反応ノート
読み込み中…