Hydrochloric Acid → N-(3-methyl-2(S)-aminobut-1-yl)phenylalanyl-methionine methyl ester hydrochloride

HRID 1900632ノート

反応式

HRID 1900632 の反応式
[CH3:1][O:2][C:3](=[O:34])[C@H:4]([CH2:30][CH2:31][S:32][CH3:33])[NH:5][C:6](=[O:29])[C@H:7]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[NH:8][CH2:9][C@@H:10]([NH:14]C(OC(C)(C)C)=O)[CH:11]([CH3:13])[CH3:12].[ClH:35]>C(OCC)(=O)C>[ClH:35].[CH3:1][O:2][C:3](=[O:34])[C@H:4]([CH2:30][CH2:31][S:32][CH3:33])[NH:5][C:6](=[O:29])[C@H:7]([CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[NH:8][CH2:9][C@@H:10]([NH2:14])[CH:11]([CH3:12])[CH3:13]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22867014N-(3-methyl-2(S)-(t-butoxycarbonylamino)but-1-yl)phenylalanylmethionine-methyl ester

生成物 1

HCID 67766427N-(3-methyl-2(S)-aminobut-1-yl)phenylalanyl-methionine methyl ester hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The product of Step C (0.74 g, 0.0015 mole) in ethyl acetate (25 ml) was treated with HCl gas at -25° C. for 30 min. The solution was stirred at room temperature for 1 hour and concentrated in vacuo to provide the title compound as a white solid (~0.79 g).

後処理

  1. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-270b19753cd24a428a1349597fb01893
出典データセット
uspto-grants-1996_11
特許番号
US05576293

反応ノート

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