Cyclopentylamine → 1-(4-Methoxy-2-nitrophenyl)-3-cyclopentylurea

HRID 1901053ノート

反応式

HRID 1901053 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[C:5]([N+:19]([O-:21])=[O:20])[CH:4]=1.[CH:22]1([NH2:27])[CH2:26][CH2:25][CH2:24][CH2:23]1>C1(C)C(C)=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH:27][CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:18])=[C:5]([N+:19]([O-:21])=[O:20])[CH:4]=1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 16227844phenyl N-(4-methoxy-2-nitrophenyl)carbamate

生成物 1

HCID 233700901-(4-Methoxy-2-nitrophenyl)-3-cyclopentylurea収率 91%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Phenyl 4-methoxy-2-nitrophenylcarbamate (1.1 g) and cyclopentylamine (0.37 g) were dissolved in xylene (10 ml) and the solution was heated under reflux for 2 hrs. After allowing the reaction solution to cool, the crystals formed was filtered, washed with xylene, and dried to give 1-(4-methoxy-2-nitrophenyl)-3-cyclopentylurea (0.97 g, 87%) as crystals.

後処理

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 2 hrs
  3. temperatureto cool
  4. customthe crystals formed
  5. filtrationwas filtered
  6. washwashed with xylene
  7. customdried

出典と根拠

ORDレコード
ord-a2c76ab4e8464bacbcbdfb48d03b9e16
出典データセット
uspto-grants-1996_11
特許番号
US05576335

反応ノート

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