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Benzene → 2-{2-[3,4-Bis(methoxycarbonyl)phenoxy]-1-methylethyl}amino-1-(3-chlorophenyl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Dimethyl 4-(2-oxopropoxy)phthalate | HCID 21832192 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-{2-[3,4-Bis(methoxycarbonyl)phenoxy]-1-methylethyl}amino-1-(3-chlorophenyl)ethanol | HCID 21832161 | — |
反応手順
Following a procedure similar to that described in Example 6, but using 2 g of 2-amino-1-(3-chlorophenyl)ethanol (prepared as described in Preparation 8), 3.73 g of dimethyl 4-(2-oxopropoxy)phthalate (prepared as described in Preparation 54), 70 ml of benzene, 60 ml of absolute methanol and 1.32 g of sodium borohydride, the title compound was obtained having an Rf=0.29 (thin layer chromatography over silica gel, using ethyl acetate as the developing solvent).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05576340 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-6ff981c6a7db4b8b883db5377fd61819 |
| 出典メモ | uspto-grants-1996_11 |