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Bromomethyl 4-methoxyphenyl ketone → 5-Bromo-2-(4-methoxybenzoyl)benzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromomethyl 4-methoxyphenyl ketone | HCID 4965 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Bromosalicylaldehyde | HCID 72863 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 5-Bromo-2-(4-methoxybenzoyl)benzofuran | HCID 2371724 | 42.6% |
反応手順
To 150 ml of acetone were suspended 20 g of 5-bromosalicylaldehyde, 22.9 g of 2-bromo-4-methoxyacetophenone and 27.6 g of anhydrous potassium carbonate. After stirring at room temperature for 4 hours, the resulting reaction solution was concentrated to dryness, and then mixed with water to collect precipitated crystals by filtration. After washing with water and subsequent recrystallization from ethanol, 14.02 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran was obtained in the form of colorless prism crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05576343 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-fd4f2b0f19b84a09aab15dcf1f9b02ac |
| 出典メモ | uspto-grants-1996_11 |