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Water → 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2-methyl-2,5-diazabicyclo[2.2.1]hept-5-yl)-4-oxo-5-vinyl-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | 2-Methyl-2,5-diazabicyclo[2.2.1]heptane | HCID 10219403 | — |
| 反応物 | 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-vinyl-3-quinolinecarboxylic acid | HCID 15297660 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2-methyl-2,5-diazabicyclo[2.2.1]hept-5-yl)-4-oxo-5-vinyl-3-quinolinecarboxylic acid | HCID 22924391 | 74.6% |
反応手順
0.93 g of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-vinyl-3-quinolinecarboxylic acid, 0.5 g of 2-methyl-2,5-diazabicyclo[2.2.1]heptane and 0.36 g of DABCO are refluxed for 2 hours in a mixture of 6 ml of acetonitrile and 3 ml of dimethylformamide. At room temperature, the reaction mixture is treated with 2 ml of water, and the solid is filtered off with suction, washed with water and dried. 0.9 g of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2-methyl-2,5-diazabicyclo[2.2.1]-hept-5-yl)-4-oxo-5-vinyl-3-quinolinecarboxylic acid is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05578604 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-786e33501018494ca55cea1629324c8a |
| 出典メモ | uspto-grants-1996_11 |