Acetic Acid → 3-(2-Tert-butoxycarbonylamino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole

HRID 1901599ノート

反応式

HRID 1901599 の反応式
C(O)(=O)C.C(O)=O.[C:8]([O:12][C:13]([N:15]1[CH:19]([CH2:20][O:21][C:22]2[C:26]3[CH:27]=[C:28]([Cl:31])[CH:29]=[CH:30][C:25]=3[O:24][N:23]=2)[CH2:18][O:17]C1(C)C)=[O:14])([CH3:11])([CH3:10])[CH3:9]>O>[C:8]([O:12][C:13]([NH:15][CH:19]([CH2:18][OH:17])[CH2:20][O:21][C:22]1[C:26]2[CH:27]=[C:28]([Cl:31])[CH:29]=[CH:30][C:25]=2[O:24][N:23]=1)=[O:14])([CH3:11])([CH3:10])[CH3:9]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 284Formic AcidHCID 23368515HCID 23368515、化合物

生成物 1

HCID 233683553-(2-Tert-butoxycarbonylamino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole収率 80.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixed solution of 19 ml of acetic acid and 19 ml of formic acid is added 3.84 g of 3-[(3-tert-butoxycarbonyl-2,2-dimethyloxazolidin-4-yl)methoxy]-5-chloro-1,2-benzoisoxazole at 20°-25° C., and they are subjected to reaction at the same temperature for one hour. Subsequently, the reaction mixture is poured into 190 ml of water and they are stirred at the same temperature for one hour. The crystals precipitated are collected by filtration, to obtain 2.78 g of 3-(2-tert-butoxycarbonylamino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole.

後処理

  1. customthey are subjected to reaction at the same temperature for one hour
  2. customThe crystals precipitated
  3. filtrationare collected by filtration

出典と根拠

ORDレコード
ord-4dafc90ca39c4c1aa2ea43603de346ed
出典データセット
uspto-grants-1996_11
特許番号
US05578627

反応ノート

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