Hydrochloric Acid → 3-(2-Amino-3-methoxyaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

HRID 1901607ノート

反応式

HRID 1901607 の反応式
C(OC([NH:8][CH:9]([CH2:22][O:23][C:24]([NH:26][O:27][CH3:28])=[O:25])[CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.Cl>CC(O)C>[ClH:21].[NH2:8][CH:9]([CH2:22][O:23][C:24]([NH:26][O:27][CH3:28])=[O:25])[CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 23368411HCID 23368411、化合物

生成物 1

HCID 233684503-(2-Amino-3-methoxyaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

実験手順

3-(2-tert-Butoxycarbonylamino-3-methoxyaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole is dissolved in 10 ml of 2-propanol, and 12.8 ml of a 2-propanol solution (7.5N) of hydrogen chloride is added, after which they are subjected to reaction at 20°-25° C. overnight. The solvent is removed from the reaction mixture by distillation under reduced pressure, and the crystals obtained are washed with 2-propanol and then collected by filtration, to obtain 0.46 g of colorless, crystalline 3-(2-amino-3-methoxyaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 199°-200° C.

後処理

  1. customafter which they are subjected to reaction at 20°-25° C. overnight
  2. customThe solvent is removed from the reaction mixture by distillation under reduced pressure
  3. customthe crystals obtained
  4. washare washed with 2-propanol
  5. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-d8fa2e9c09554900bf79a772e3d4f3f1
出典データセット
uspto-grants-1996_11
特許番号
US05578627

反応ノート

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