Dimethylformamide → HCID 53837598、化合物

HRID 1901697ノート

反応式

HRID 1901697 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[O:5][CH2:6][C@H:7]([OH:21])[CH2:8][NH:9][C@H:10]([CH3:20])[CH2:11][O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14].CN(C)[CH:27]=[O:28]>>[Si:13]([O:12][CH2:11][C@H:10]([N:9]1[CH2:8][C@H:7]([CH2:6][O:5][C:4]2[CH:22]=[CH:23][CH:24]=[C:2]([Cl:1])[CH:3]=2)[O:21][C:27]1=[O:28])[CH3:20])([C:16]([CH3:17])([CH3:18])[CH3:19])([CH3:14])[CH3:15]

参加物

3

反応物 2

HCID 6228DimethylformamideHCID 22867566HCID 22867566、化合物

生成物 1

HCID 53837598HCID 53837598、化合物

実験手順

A procedure similar to that described in Preparation 11 was repeated, except that 3.45 g of 1(R)-(3-chlorophenoxymethyl)-2-(2-t-butyldimethylsilyloxy-1(R)-methylethylamino)ethanol (prepared as described in Preparation 42), 1.78 g of N,N'-carbonyldiimidazole and 30 ml of anhydrous dimethylformamide were used, to give 3.52 g of the title compound having an Rf value of 0.74 (on silica gel thin layer chromatography, using a 1:1 by volume mixture of ethyl acetate and hexane as the developing solvent) and having [α]D =-53.3° (methanol, c=1.020).

後処理

  1. customA procedure similar to that described in Preparation 11

出典と根拠

ORDレコード
ord-6e26860229dd43f982cd11c28eb2d4fd
出典データセット
uspto-grants-1996_11
特許番号
US05578620

反応ノート

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