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Boron tribromide → 1-[(4-chlorophenyl)-methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron tribromide | HCID 25134 | — |
| 反応物 | 1-(4-Chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acid | HCID 4059895 | — |
| 反応物 | 1-[(4-Chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester | HCID 53817482 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-[(4-chlorophenyl)-methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid | HCID 23368791 | — |
反応手順
1-[(4-Chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester. Using the methods in Example 63, Part C, 1.2 g (3.5 mmol) of 1-[(4-chlorophenyl)methyl]-5-methoxy-2-methyl-1H-indole-3-acetic acid was treated with 15 mL of 1M BBr3 in CH2Cl2 to give crude 1-[(4-chlorophenyl)-methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid which was treated with sulfuric acid in MeOH to give 1.2 g of 1-[(4-chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05578634 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-3236222f72e941c788dc77e1abfa8ce4 |
| 出典メモ | uspto-grants-1996_11 |