Methylamine → HCID 178485067、化合物

HRID 1902276

反応式

HRID 1902276 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][S:9][CH2:10][CH2:11][NH:12][C:13](=[N:16][C:17]#[N:18])SC)[N:3]=1.[CH3:19][NH2:20]>C(O)C>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][S:9][CH2:10][CH2:11][NH:12][C:13]([NH:20][CH3:19])=[N:16][C:17]#[N:18])[N:3]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 178503928HCID 178503928、化合物

生成物 1

HCID 178485067HCID 178485067、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4-amino-2-[2-(3-cyano-2-methylisothioureido)ethylthiomethyl]pyrimidine (0.75 g.) in 33% w/v methylamine in ethanol (15 ml.) was left at room temperature for 18 hours. The solution was concentrated to 5 ml., cooled in ice, and the crystalline precipitate collected to give 4-amino-2-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]pyrimidine (0.52 g.), m.p. 189°-190°.

後処理

  1. concentrationThe solution was concentrated to 5 ml
  2. temperature, cooled in ice
  3. customthe crystalline precipitate collected

出典と根拠

ORDレコード
ord-eee5d5b83a6a40d99c8e356e3fc4af14
出典データセット
uspto-grants-1982_12
特許番号
US04362728

関連ノート

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