Methylamine → HCID 178485047、化合物

HRID 1902281ノート

反応式

HRID 1902281 の反応式
[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[N:22][C:23]#[N:24])SC)[N:8]=1.[CH3:28][NH2:29]>C(O)C>[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]([NH:29][CH3:28])=[N:22][C:23]#[N:24])[N:8]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 178503915HCID 178503915、化合物

生成物 1

HCID 178485047HCID 178485047、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine (0.17 g.) in 33% w/v methylamine in ethanol was left at room temperature for 18 hours and then evaporated to dryness. The residue was triturated with ether and the insoluble solid collected and recrystallised from ethyl acetate to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(2-cyano-3-methylguanidino)-butylthio]pyrimidine, m.p. 179°-180°.

後処理

  1. customevaporated to dryness
  2. customThe residue was triturated with ether
  3. customthe insoluble solid collected
  4. customrecrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-8b4d628aa18d496385354da6bf079347
出典データセット
uspto-grants-1982_12
特許番号
US04362728

反応ノート

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