Diclofenac sodium → 1-(4-Amino-3-bromo-5-cyclohexylaminomethyl-benzoyloxy)-5-{2-[(2,6-dichlorophenyl)-amino]-phenylacetoxy}-n-pentane

HRID 1902351

反応式

HRID 1902351 の反応式
[NH2:1][C:2]1[C:16]([CH2:17][NH:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:15][C:5]([C:6]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]Cl)=[O:7])=[CH:4][C:3]=1[Br:25].[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=1[NH:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[CH2:41][C:42]([O-:44])=[O:43].[Na+]>>[NH2:1][C:2]1[C:16]([CH2:17][NH:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:15][C:5]([C:6]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:44][C:42](=[O:43])[CH2:41][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[NH:34][C:28]2[C:27]([Cl:26])=[CH:32][CH:31]=[CH:30][C:29]=2[Cl:33])=[O:7])=[CH:4][C:3]=1[Br:25]

参加物

3

反応物 2

HCID 5018304Diclofenac sodiumHCID 205159935-(4-Amino-3-bromo-5-cyclohexylaminomethyl-benzoyloxy)-n-pentyl chloride

生成物 1

HCID 205164391-(4-Amino-3-bromo-5-cyclohexylaminomethyl-benzoyloxy)-5-{2-[(2,6-dichlorophenyl)-amino]-phenylacetoxy}-n-pentane

実験手順

This compound was prepared from 5-(4-amino-3-bromo-5-cyclohexylaminomethyl-benzoyloxy)-n-pentyl chloride and sodium 2-[(2,6-dichlorophenyl)-amino]-phenylacetate analogous to Example 8.

出典と根拠

ORDレコード
ord-acf9831c69b042ac92af26eef4fd2e0b
出典データセット
uspto-grants-1982_12
特許番号
US04362738

関連ノート

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