Hydrochloric Acid → (2,4-Dihydroxyphenyl)(4-methoxyphenyl)methanone

反応式

[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:14])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.[C:16]1([CH:23]=[CH:22][CH:21]=[C:19]([OH:20])[CH:18]=1)[OH:17].[N+](C1C=CC=CC=1)([O-])=O.Cl>>[OH:17][C:16]1[CH:18]=[C:19]([OH:20])[CH:21]=[CH:22][C:23]=1[C:5]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)=[O:14]

参加物

反応物 5

HCID 313Hydrochloric Acid

HCID 5054Resorcinol

HCID 7416Nitrobenzene

HCID 7477p-Anisoyl chloride

HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 350227(2,4-Dihydroxyphenyl)(4-methoxyphenyl)methanone

実験手順

Aluminum chloride (48 gm, 0.36 moles) was added gradually, with stirring to a mixture of 31 grams (0.18 moles) of anisoyl chloride, 19.82 grams (0.18 moles) of resorcinol and 300 ml. of dry nitrobenzene during 60 minutes. Sixty hours later the reaction mixture was poured on 200 grams of ice and 100 ml. of concentrated hydrochloric acid. After removal of the nitrobenzene with steam the residual crystalline solid product was washed with water and collected. The cake was then washed with cold (-50 degrees C.) methanol to remove tarry impurities and dried.