1,8-Dibromooctane → 8-Phenoxyoctyl bromide

反応式

[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[Br:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Br>>[O:7]([CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][Br:9])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 2

HCID 783101,8-Dibromooctane

HCID 4445035Phenolate Sodium

生成物 1

HCID 129593778-Phenoxyoctyl bromide収率 75%

実験手順

Preparation analogously to Example 38 by the reaction of sodium phenolate with 1,8-dibromooctane to give 8-phenoxy-1-bromooctane (b.p.11 =196°-202°; yield 75%) which is reacted with excess 5-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate. Isolation is hydrochloride. Yield, after recrystallisation from ethanol/isopropanol: 62%.

後処理

customPreparation analogously to Example 38

出典と根拠

ORDレコード: ord-9936a70066974ca4b92d0849113ca6bc
出典データセット: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04363805

反応ノート

読み込み中…

参加物