3-[2-(4-Fluorophenyl)-1,3-dioxolan-2-yl]-1-propanamine → HCID 13083942、化合物

HRID 1902843ノート

反応式

HRID 1902843 の反応式
[C:1]1(=[O:8])[CH:7]=[CH:6][CH2:5][CH2:4][CH:3]=[CH:2]1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2([CH2:21][CH2:22][CH2:23][NH2:24])[O:20][CH2:19][CH2:18][O:17]2)=[CH:12][CH:11]=1>CO>[F:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2([CH2:21][CH2:22][CH2:23][N:24]3[CH:6]4[CH2:5][CH2:4][CH:3]3[CH2:2][C:1](=[O:8])[CH2:7]4)[O:17][CH2:18][CH2:19][O:20]2)=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 64515393-[2-(4-Fluorophenyl)-1,3-dioxolan-2-yl]-1-propanamineHCID 109204632,6-Cycloheptadien-1-one

生成物 1

HCID 13083942HCID 13083942、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a flask equipped with a nitrogen gas inlet, addition funnel and magnetic stirrer is charged 2.7 g. (0.025 mol) of 2,6-cycloheptadienone and 90 ml. of methanol. The solution is stirred and 5.63 g. (0.025 mol) of 2-(4-fluorophenyl)-1,3-dioxolane-2-propanamine in 90 ml. of methanol is added over 30 minutes. After the addition, the reaction is allowed to stir for 20 hrs. The solution is then concentrated in vacuo to afford an oil. Chromatography on 500 g. of silica gel gives, after evaporation of solvent, 8-{3-[2-(4-fluorophenyl)1,3-dioxolan-2-yl]-propyl}-8-azabicyclo-[3.2.1]octan-3-one as an oil.

後処理

  1. customTo a flask equipped with a nitrogen gas inlet, addition funnel and magnetic stirrer
  2. additionis charged 2.7 g
  3. additionAfter the addition
  4. stirringto stir for 20 hrs
  5. concentrationThe solution is then concentrated in vacuo
  6. customto afford an oil
  7. customof silica gel gives
  8. customafter evaporation of solvent, 8-{3-[2-(4-fluorophenyl)1,3-dioxolan-2-yl]-propyl}-8-azabicyclo-[3.2.1]octan-3-one as an oil

出典と根拠

ORDレコード
ord-3851e41f228a416a9ddb4541fb9a7482
出典データセット
uspto-grants-1982_12
特許番号
US04366154

反応ノート

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