2,6-Difluorophenyl isothiocyanate → HCID 20513898、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]=[C:10]=[S:11].[CH2:12]([O:19][NH:20][CH2:21][CH2:22][N:23]1[C:27](=[O:28])[C:26]2=[CH:29][CH:30]=[CH:31][CH:32]=[C:25]2[C:24]1=[O:33])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1C=CC=CC=1>[CH2:12]([O:19][N:20]([CH2:21][CH2:22][N:23]1[C:27](=[O:28])[C:26]2=[CH:29][CH:30]=[CH:31][CH:32]=[C:25]2[C:24]1=[O:33])[C:10]([NH:9][C:3]1[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=1[F:8])=[S:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
4
実験手順
A solution of 19.68 g of 2,6-difluorophenylisothiocyanate and 34.1 g of N-{2-[N-(benzyloxy)amino]ethyl}phthalimide in 150 ml of benzene is heated to boiling under reflux for 6 hours. The cooled solution is separated from a slight precipitate and then evaporated in vacuo. The residual oil crystallizes from isopropyl ether. There is obtained 1-(benzyloxy)-3-(2,6-difluorophenyl)-1-(2-phthalimidoethyl)-2-thiourea of melting point 141°-143° (ether/methylene chloride).