Formamide → HCID 14456868、化合物

HRID 1903012ノート

反応式

HRID 1903012 の反応式
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:9]([CH2:10]I)[CH2:8][C:7]1=[O:12].[CH:19]([NH2:21])=O.[C-]#N.[Na+]>>[C:19]([CH2:10][CH:9]1[N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7](=[O:12])[CH2:8]1)#[N:21]

参加物

4

反応物 3

HCID 713FormamideHCID 8929Sodium CyanideHCID 14456867HCID 14456867、化合物

生成物 1

HCID 14456868HCID 14456868、化合物収率 70%

実験手順

A solution of 1.2 g. (3.3 mmoles) of 1-(2,4-dimethoxybenzyl)-4-(iodomethyl)-2-azetidinone prepared according to Example 13 in 5 ml. ofddimethyl formamide is stirred with 0.35 g. (7 mmoles) of sodium cyanide for 48 hours, at room temperature. The solution is then poured onto 30 ml. of water and extracted with five 20-ml. portions of ether. The ethereal solution is dried with magnesium sulfate, decolored with activated carbon, filtered and the filtrate is evaporated in vacuo. 0.6 g. (70%) of the named compound are obtained.

後処理

  1. customat room temperature
  2. additionThe solution is then poured onto 30 ml
  3. extractionof water and extracted with five 20-ml
  4. dry with materialThe ethereal solution is dried with magnesium sulfate
  5. filtrationfiltered
  6. customthe filtrate is evaporated in vacuo

出典と根拠

ORDレコード
ord-1b7ff7b5be72475fb29a4d64ec6d74b3
出典データセット
uspto-grants-1984_03
特許番号
US04435322

反応ノート

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