Methylprednisolone → 11beta,17-Dihydroxy-6alpha-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione

HRID 1903059

反応式

HRID 1903059 の反応式
[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:27])[C:9]([C@@H:10]([CH3:25])[CH2:11]2)=[CH:8][C:7](=[O:26])[CH:6]=[CH:5]1.[CH3:28][O:29][CH2:30][CH2:31][C:32](Cl)=[O:33]>>[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][O:19][C:32](=[O:33])[CH2:31][CH2:30][O:29][CH3:28])[C@H:12]2[C@H:3]1[C@:4]1([CH3:27])[C:9]([C@@H:10]([CH3:25])[CH2:11]2)=[CH:8][C:7](=[O:26])[CH:6]=[CH:5]1

参加物

3

反応物 2

HCID 6741MethylprednisoloneHCID 27597283-Methoxypropanoyl chloride

生成物 1

HCID 5662029311beta,17-Dihydroxy-6alpha-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione

実験手順

Under the conditions of Example 3(a), 15.0 g of 11β,17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione is reacted with 3-methoxypropionic acid chloride, worked up, and purified, thus isolating 14.3 g of 11β,17-dihydroxy-6α-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione, mp 230° C.

後処理

  1. custompurified

出典と根拠

ORDレコード
ord-798436e653864e28a3f8301899f6db16
出典データセット
uspto-grants-1984_03
特許番号
US04435390

関連ノート

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