2-Phenoxy-4-(4-formylpiperazino)pyrimidine → 2-Phenoxy-4-piperazinopyrimidine

HRID 1903086

反応式

HRID 1903086 の反応式
[O:1]([C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][N:17](C=O)[CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[O:1]([C:8]1[N:13]=[C:12]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 138695712-Phenoxy-4-(4-formylpiperazino)pyrimidine

生成物 1

HCID 138695632-Phenoxy-4-piperazinopyrimidine収率 64%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

2-Phenoxy-4-(4-formylpiperazino)pyrimidine (2.6 g) in methanol (27 ml) and 2 N hydrochloric acid (6.9 ml) was left at room temperature for 24 hours and then heated on a steam bath for 30 minutes. The solvent was evaporated in vacuo and the residue re-crystallized twice from isopropanol to give 2-phenoxy-4-piperazinopyrimidine (1.5 g) characterized spectroscopically, and used directly.

後処理

  1. temperatureheated on a steam bath for 30 minutes
  2. customThe solvent was evaporated in vacuo
  3. customthe residue re-crystallized twice from isopropanol

出典と根拠

ORDレコード
ord-dc8b28cf533f46818e4d50a65d641ddf
出典データセット
uspto-grants-1984_03
特許番号
US04435401

関連ノート

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