Hydrochloric Acid → HCID 131713413、化合物
反応式
[F:1][CH:2]([F:25])[CH:3]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:4][CH2:5][N:6]1C(=O)C2=CC=CC=C2C1=O.[ClH:26]>>[ClH:26].[ClH:26].[F:1][CH:2]([F:25])[CH:3]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:4][CH2:5][NH2:6]参加物
3
反応条件
- 温度
- 110 °C
実験手順
A solution of N-(4,4-difluoro-3-benzylaminobutyl) phthalimide (0.585 g, 1.72 mM) prepared as in Step D in concentrated hydrochloric acid (50 ml) is heated at 110° C. for 15 hours. The solvent is evaporated in vacuo, and the residue is taken up in cold water (50 ml). The aqueous phase is filtered and concentrated in vacuo, washed three times with diethyl ether, and then evaporated to dryness. The oily residue is triturated several times with isopropanol. The solvent is removed in vacuo yielding a white foam: 0.490 g (quantitative yield) of the required compound.
後処理
- customThe solvent is evaporated in vacuo
- filtrationThe aqueous phase is filtered