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Sodium Chloride → 3-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Pyrocarbonate | HCID 15238643 | — |
| 反応物 | 3-Amino-4,4-difluorobutanoic acid hydrochloride | HCID 71403098 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic acid | HCID 20468453 | — |
反応手順
A mixture of 4,4-difluoro-3-amino-butanoic acid, hydrochloride prepared as in Step C (0.702 g, 4 mM), ditertiobutyl dicarbonate (0.916 g, 4.2 mM), sodium bicarbonate (0.336 g, 4 mM) in tetrahydrofuran and water (6 ml of a 1:1 mixture) is heated at reflux for 48 hours. The resulting solution is saturated with sodium chloride and extracted three times with chloroform. The organic phase is dried over anhydrous magnesium sulfate, and the solvent evaporated in vacuo yielding a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04435425 |
| 出典データセット | uspto-grants-1984_03 |
| ORD ID | ord-e51cfa98c7f84b508c523cc99e55a595 |
| 出典メモ | uspto-grants-1984_03 |