Ammonia → 2-Hydroxybenzonitrile

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A reaction tube having an inside diameter of 5 cm was filled with 293 g of a supported catalyst composed of 3.75% by weight of boron phosphate (P2O5 /B2O3 mole ratio=1) deposited on an alumina carrier spherical alumina carrier having a pore diameter of about 1 micron. Octyl salicylate and ammonia were introduced into the reaction tube at a rate of 108.9 g/hr and 148 g/hr, respectively, and reacted in the vapor phase at 415° C. The mole ratio of ammonia to octyl salicylate in the gaseous mixture was 20:1, and the contact time was 11 seconds. When the reaction was continued for 8 hours, 375.3 g of o-hydroxybenzonitrile was obtained from 871.2 g of octyl salicylate. The yield was 90.5% by weight. Gas-chromatographic analysis showed that only 2.6% by weight of phenol was formed as a by-product.

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